The factors that affect the dose-response relationship in cells include:

back (1K)       next (1K)

  • Physical factors of the radiation interacting with the cells such as LET and Dose rate.

  • Chemical factors such as sensitizers, which make the tissue more sensitive to radiation damage, and radioprotectants, which provide some protection from radiation effects. (e.g., Potassium iodide administered before or during exposure to radioiodine can greatly decrease the dose to the thyroid.)

  • Biological factors such as cell cycle and intracellular repair. During certain phases of mitotic division cells are much more susceptible to damage. Cells can also repair most damage caused by radiation unless the exposure causes too many effects in which case the cell may die or repair itself incorrectly (mutation).

  • Page 94

    back (1K)       next (1K)